个人简历
娄筱叮
博士，教授，博导，中国地质大学(武汉)材料与化学学院
联系方式：louxiaoding@cug.edu.cn
课题组网站：http://xiafan.cug.edu.cn/
教育经历（按时间倒序排序）：
2007/9 - 2012/6，武汉大学，有机化学，博士，
导师：李振教授
2004/9 - 2007/6，武汉大学，化学基地班，交流生
2003/9 - 2004/6，湖北工程学院，化学教育学,学士
工作经历（科研与学术工作经历，按时间倒序排序）：
2017/1-至今，中国地质大学(武汉)，材料与化学学院，教授
2016/4-2016/10，加州大学圣塔芭芭拉分校，物理系，访问学者，合作导师：Alan J. Heeger教授（2000年诺贝尔奖得主）
2014/11-2016/12，华中科技大学，化学与化工学院，副教授
2013/8-2014/10，华中科技大学，化学与化工学院，讲师
2012/8-2013/7，香港科技大学，高分子系，Research Associate，合作导师：唐本忠教授
主持或参加科研项目及人才计划项目情况（按时间倒序排序）：
1、 国家自然科学基金优秀青年基金，21722507、化学生物传感、2018/01-2020/12、130万元、在研、主持。
2、 浙江省自然科学基金一般项目，LY18B050002、基于多标志物联合技术的微纳米器件的构筑及其在乳腺癌早期检测中的应用、2018/01-2020/12、10万、在研、主持。
3、 国家自然科学基金面上项目，21574048、亲疏水可调DNA-AIE高分子复合探针的构建及其传感性能研究、2016/01-2019/12、65万元、在研、主持。
4、 国家自然科学基金青年项目，21405054、微纳米限域空间内聚集诱导发光分子的组装行为在生物/化学传感器中的应用、2015/01-2017/12、25万元、结题、主持。
5、 湖北省自然科学基金面上项目，2014CFB1012、聚集诱导发光分子在微纳米孔道中传感性能的研究、2014/01-2015/12、3万元、结题、主持。
6、 国家重点研发计划重大科学仪器设备开发专项，2016YFF0100800、2017/01-2019/12、基于微流控高通量芯片的新型高灵敏传感系统开发及应用、100万元、在研、子课题负责人。
目前研究兴趣集中在有机光电材料在化学生物传感器中的应用方面。在国际核心期刊上发表/接收SCI论文91篇（影响因子大于5的论文62篇,影响因子大于10的论文11篇,高被引论文5篇）。相关研究成果已被国际知名刊物引用2300余次H因子为27。
作为第一作者或通讯作者在Chem. Soc. Rev.(1篇，影响因子40.182), Angew. Chem. Int. Ed. (2篇，影响因子12.102), Adv. Mater. (1篇，影响因子21.950), Adv. Funct. Mater. (1篇，影响因子13.325), Nano Energy (1篇，影响因子13.120), Anal. Chem. (10篇，影响因子6.042), Chem. Sci. (2篇，影响因子9.063), Small (3篇，影响因子9.598), Biomaterials (1篇，影响因子8.806), Theranostics (1篇，影响因子8.537), Biosens. Bioelectron (2篇，影响因子8.173), ACS Appl. Mater. Interfaces (3篇，影响因子8.097)，Nanoscale (2篇，影响因子7.233), NPG Asia Mater. (2篇，影响因子7.208), Chem. Comm. (4篇，影响因子6.290)等国际一流学术刊物发表研究论文58篇,共计影响因子超过400。
国家优秀青年科学基金获得者，湖北省青联十三届委员会常委，湖北省第十二次妇女代表，湖北省青年科学协会委员，中国生物材料学会影像材料与技术分会第一届委员。主持国家自然科学基金面上项目1项，国家自然科学基金青年项目1项，国家重点研发计划重大科学仪器设备开发专项子课题1项，湖北省自然科学基金面上项目1项,浙江省自然科学基金一般项目1项。参与主持编写英文著作“Biosensors based on sandwich assays”一部（Springer出版社）。授权专利6项。
部分研究成果列表（2015-今）
1. Duan, Ruixue, Lou, Xiaoding(*) and Xia, Fan(*), The development of nanostructure assisted isothermal amplification in biosensors, Chemical Society Reviews, 2016, 45, 1738-1749. IF=40.182; Times Cited: 40
2. Cheng, Yong(#), Sun, Chunli(#), Liu, Rui (#), Yang, Juliang, Dai, Jun, Zhai, Tianyou, Lou, Xiaoding(*) and Xia, Fan(*),A multifunctional peptide-conjugated AIEgen for efficient and sequential targeted gene delivery into the nucleus, Angewandte Chemie International Edition, 2019,doi.org/10.1002/anie.201901527. IF=12.102; Times Cited: 0
3. Cheng, Yong(#), Dai, Jun(#), Sun, Chunli(#), Liu, Rui, Zhai, Tianyou, Lou, Xiaoding(*) and Xia, Fan(*), An intracellular H2O2-responsive AIEgen for the peroxidase-mediated selective imaging and inhibition of inflammatory cells,Angewandte Chemie International Edition, 2018, 57, 3123-3127. IF=12.102; Times Cited: 22(highly cited paper)
4. Gao, Pengcheng, Hu, Lintong, Liu, Nannan, Yang, Zekun, Lou,Xiaoding(*), Zhai, Tianyou(*), Li, Huiqiao, and Xia, Fan(*), Functional “janus” annulus in confined channel, Advanced Materials, 2016, 28, 460-465. IF=21.950; Times Cited: 18
5. Wang, Fengmei, Shifa, Tofik Ahmed., Yu, Peng, He, Peng, Liu, Yang, Wang, Feng, Wang, Zhenxing, Zhan, Xueying, Lou, Xiaoding(*), Xia, Fan(*) and He, Jun(*), New Frontiers on van der Waals Layered Metal Phosphorous Trichalcogenides,Advanced Functional Materials, 2018, 1802151. IF=13.325; Times Cited: 4
6. Yu, Peng, Wang, Fengmei(*), Shifa, Tofik Ahmed, Zhan, Xueying, Lou, Xiaoding(*), Xia, Fan(*), He, Jun(*), Earth abundant materials beyond transition metal dichalcogenides: A focus on electrocatalyzing hydrogen evolution reaction,Nano Energy, 2019, 58, 244-276. IF=13.120; Times Cited: 0
7. Hu, Rong, Chen, Bin, Wang, Zhiming, Qin, Anjun, Zhao, Zujin(*), Lou, Xiaoding(*), Tang, Ben Zhong(*), Intriguing "chameleon" fluorescent bioprobes for the visualization of lipid droplet-lysosome interplay,Biomaterials, 2019, 203, 43-51. IF=8.806; Times Cited: 0
8. Wu, Feng(#),Wu, Xia(#),Duan, Zhijuan,Huang, Yu,Lou, Xiaoding(*),Xia, Fan(*) Biomacromolecule-Functionalized AIEgens for Advanced Biomedical Studies, Small, 2019, DOI:10.1002/smll.201804839. IF=9.598; Times Cited: 0
9. Cheng, Yong, Sun, Chunli, Ou, Xiaowen, Liu, Bifeng, Lou, Xiaoding(*), and Xia, Fan(*), Dual-targeted peptide-conjugated multifunctional fluorescent probe with AIEgen for efficient nucleus-specific imaging and long-term tracing of cancer cells. Chemical Science, 2017, 8, 4571-4578. IF=9.063; Times Cited: 24
10. Chen, Yanxia, Min, Xuehong, Zhang, Xiqi, Zhang, Feilong, Lu, Simeng, Xu, Li-Ping(*), Lou, Xiaoding(*), Xia, Fan, Zhang, Xueji(*), Wang, Shutao, AIE-based superwettable microchips for evaporation and aggregation induced fluorescence enhancement biosensing. Biosensors and Bioelectronics, 2018, 111, 124-130. IF=8.173; Times Cited: 4
11. Yi, Xiaoqing(#), Dai, Jun(#), Han,Yingyan, Xu, Min, Zhang, Xiaojin, Zhen, Shijie, Zhao, Zujin(*), Lou, Xiaoding(*), Xia, Fan(*), A high therapeutic efficacy of polymeric prodrug nano-assembly for a combination of photodynamic therapy and chemotherapy, Communications Biology, 2018, 1, 202. Times Cited: 0
12. Zhan, Shenshan, Pan, Yong, Gao, Zhongfeng, Lou, Xiaoding(*), Xia, Fan(*), Biological and chemical sensing applications based on special wettable surfaces, Trends in Analytical Chemistry, 2018, 108, 183-194, IF=7.030; Times Cited: 0
13. Xu, Xuemei, Zhao, Wei, Gao, Pengcheng, Li, Huiqing, Feng, Guang, Zhao, Zujin, Lou, Xiaoding(*), Coordination of the electrical and optical signals revealing nanochannels with an “onion-like” gating mechanism and its sensing application, NPG Asia Materials, 2016, 2016, 8, e234. IF=7.208; Times Cited: 8
14. Gao, Zhongfeng(#), Sann, Ei Ei(#), Lou, Xiaoding(#), Liu, Renyi, Dai, Jun(*), Zuo, Xiaolei, Xia, Fan(*) and Jiang Lei,Naked eye point-of-care testing platform based on pH-responsive superwetting surface: toward non-invasive detection of glucose,NPG Asia Materials, 2018, 10,177-189. IF=7.208; Times Cited: 3
15. Chang, Zhengfeng, Jing, Lingmin, Chen, Bin, Zhang, Mengshi, Liu, Junjie, Ye, Yanchun, Lou, Xiaoding(*), Zhao, Zujin(*), Liu, Bin(*), Wang, Jinliang(*), Tang, Ben Zhong, Rational design of asymmetric red fluorescent probes for live cell imaging with high AIE effect and large two-photon absorption cross section using tuneable terminal groups, Chemical Science, 2016, 7, 4527-4536. IF=9.063; Times Cited: 43
16. Wang, Xudong(#), Dai, Jun(#), Min, Xuehong, Yu, Zhihua, Cheng, Yong, Huang, Kaixun, Yang, Juliang, Yi, Xiaoqing, Lou, Xiaoding (*), Xia, Fan(*), DNA-Conjugated Amphiphilic Aggregation-Induced Emission Probe for Cancer Tissue Imaging and Prognosis Analysis.Analytical Chemistry, 2018, 90,8162-8169. IF=6.042; Times Cited: 6
17. Long, Zi(#), Zhan, Shenshan (#), Gao, Pengcheng, Wang, Yongqian, Lou, Xiaoding(*), Xia, Fan(*), Recent advances in solid nanopore/channel analysis. Analytical Chemistry, 2018, 90, 577-588.IF=6.042; Times Cited: 14 (highly cited paper)
18. Li, Xinchun, Zhang, Tianchi, Gao, Pengcheng, Wei, Benmei, Jia, Yongmei, Cheng, Yong, Lou, Xiaoding(*), Xia, Fan(*), Integrated Solid-state Nanopore Electrochemistry Array for Sensitive, Specific, and Label-free Biodetection, Langmuir, 2018,34, 14787-14795. IF=3.789; Times Cited: 1
19. Jia,Yongmei, Wu, Feng, Liu, Peilian, Zhou, Guohua, Yu, Biao, Lou, Xiaoding(*), Xia, Fan(*), A label-free fluorescent aptasensor for the detection of Aflatoxin B1 in food samples using AIEgens and graphene oxide, Talanta, 2019, 198, 71-77.IF=4.244; Times Cited: 1
20. Chen, Dugang(#), Yang, Juliang(#), Dai, Jun(*), Lou, Xiaoding(*), Zhong, Cheng, Yu, Xianglin, Xia, Fan, A low background D-A-D type fluorescent probe for imaging of biothiols in living cells,Journal of Materials Chemistry B, 2018, 6,5248-5255. IF=4.776, Times Cited: 3
21. Jia, Yongmei(#), Gao, Pengcheng(#), Zhuang, Yuan(#), Miao, Mao, Lou, Xiaoding(*), Xia, Fan, Facile probe design: fluorescent amphiphilic nucleic acid probes without quencher providing telomerase activity Imaging inside living cells, Analytical Chemistry, 2016, 88, 6621-6626. IF=6.042; Times Cited: 22
22. Zhang, Xiaojin, Lou, Xiaoding(*), Xia, Fan(*),Advances in the detection of telomerase activity using isothermal amplification, Theranostics, 2017,7, 1847-1862. IF=8.537; Times Cited: 13
23. Ou, Xiaowen, Lou, Xiaoding(*), Xia, Fan(*),A highly sensitive DNA-AIEgen-based “turn-on” fluorescence chemosensor for amplification analysis of Hg2+ions in real samples and living cells,Science China Chemistry, 2017, 60, 663-669. IF=4.448; Times Cited: 8
24. Min, Xuehong, Xia, Lei, Zhuang, Yuan, Wang, Xudong, Du, Jie, Zhang, Xiaojin, Lou, Xiaoding(*), Xia, Fan(*),An AIEgens and exonuclease III aided quadratic amplification assay for detecting and cellular imaging of telomerase activity,Science Bulletin, 2017, 62,997-1003, IF=4.136; Times Cited: 4
25. Wang, Xudong, Xu, Min, Huang, Kaixun, Lou, Xiaoding(*), Xia, Fan (*), Recent Development of AIEgens/nucleic Acid Nanostructure for Bioanalytical Application, 2018, Chemistry - An Asian Journal 2019, 14, 689-699. IF=3.692; Times Cited: 0
26. Zhuang, Yuan(#), Shang, Chunli(#), Lou, Xiaoding(*),Xia, Fan(*), Construction of AIEgens-based bioprobe with two fluorescent signals for enhanced monitor of extracellular and intracellular telomerase activity, Analytical Chemistry,2017, 89, 2073-2079. IF=6.042; Times Cited: 16
27. Ou, Xiaowen, Wei, Benmei, Zhang, Zhenyu, Zhang, Mengshi, Zhuang, Yuan, Gao, Pengcheng(*), Lou, Xiaoding(*), Xia, Fan, Tang, Ben Zhong, Detection of UVA/UVC-induced damage of p53 fragment by rolling circle amplification with AIEgens, Analyst, 2016, 141,4394-4399. IF=3.864; Times Cited: 2
28. Ou, Xiaowen, Hong, Fan, Zhang, Zhenyu, Cheng, Yong, Zhao, Zujin, Gao, Pengcheng, Lou, Xiaoding(*), Xia, Fan, Wang, Shutao, A highly sensitive and facile graphene oxide-based nucleic acid probe: label-free detection of telomerase activity in cancer patient's urine using AIEgens, Biosensors and Bioelectronics, 2016, 141, 4394-4399. IF=8.173; Times Cited: 20
29. Liu, Nannan(#), Li, Cao(#), Zhang, Tianchi, Hou, Ruizuo, Xiong, Zhiping, Li, Zeyong, Wei, Benmei, Yang, Zekun, Gao, Pengcheng(*), Lou, Xiaoding(*), Zhang, Xianzheng, Guo, Wei, Xia, Fan, Fabrication of "plug and play" channels with dual responses by host-guest interactions, Small, 2017, 13(1600287):1~6. IF=9.598; Times Cited: 8
30. Lou, Xiaoding, Zhao, Zujin(*), Tang, Ben Zhong(*), Organic dots based on AIEgens for two-photon fluorescence bioimaging, Small, 2016,12, 6430-6450. IF=9.598; Times Cited: 32
31. Lou, Xiaoding, Zhang, Mengshi, Zhao, Zujin, Min, Xuehong, Hakeem, Abdul, Huang, Fujian, Gao, Pengcheng, Xia, Fan (*), Tang, Ben Zhong,A photostable AIE fluorogen for lysosome-targetable imaging of living cells,Journal of Materials Chemistry B, 2016, 4, 5412-5417. IF= 4.776; Times Cited: 9
32. Cheng, Yong, Huang, Fujian, Min, Xuehong, Gao, Pengcheng, Zhang, Tianchi, Li, Xinchun, Liu, Bifeng, Hong, Yuning, Lou, Xiaoding(*), Xia, Fan(*), Protease-responsive prodrug with aggregation-induced emission probe for controlled drug delivery and drug release tracking in living cells, Analytical Chemistry, 2016, 88, 8913-8919. IF=6.042; Times Cited: 23
33. Min, Xuehong(#), Zhang, Mengshi(#), Huang, Fujian, Lou, Xiaoding(*), Xia, Fan, Live cell microRNA imaging using exonuclease III-aided recycling amplification based on AIEgens, ACS Applied Materials & Interfaces, 2016, 8, 8998-9003. IF=8.097; Times Cited: 29
34. Zhuang, Yuan(#), Xu, Qi(#), Huang, Fujian, Gao, Pengcheng, Zhao, Zujin, Lou, Xiaoding(*), Xia, Fan, Ratiometric fluorescent bioprobe for highly reproducible detection of telomerase in bloody urines of bladder cancer patients, ACS Sensors, 2016, 1, 572-578; IF=5.711 Times Cited: 22
35. Xu, Xuemei, Hou, Ruizuo, Gao, Pengcheng, Miao, Mao, Lou, Xiaoding(*), Liu, Bifeng, Xia, Fan, Highly robust nanopore-based dual-signal-output ion detection system for achieving three successive calibration curves, Analytical Chemistry, 2016, 88, 2386-2391. IF=6.042; Times Cited: 8
36. Zhuang, Yuan, Huang, Fujian, Xu, Qi, Zhang, Mengshi, Lou, Xiaoding(*), Xia, Fan, Facile, Fast-responsive and photostable imaging of telomerase activity in living cells with a fluorescence turn-on manner, Analytical Chemistry, 2016, 88, 3289-3294. IF=6.042; Times Cited: 37
37. Hakeem, Abdul, Zahid, Fouzia, Duan, Ruixue, Asif, Muhammad, Zhang, Tianchi, Zhang, Zhenyu, Cheng, Yong, Lou, Xiaoding(*), Xia, Fan(*), Cellulose conjugated FITC-labelled mesoporous silica nanoparticles: intracellular accumulation and stimuli responsive doxorubicin release, Nanoscale, 2016, 8, 5089-5097. IF=7.233; Times Cited: 24
38. Liu, Nannan, Hou, Ruizuo, Gao, Pengcheng, Lou, Xiaoding(*), Fan Xia, Sensitive Zn2+sensor based on biofunctionalized nanopores by combination of DNAzyme and DNA supersandwich structures,Analyst, 2016, 141, 3626-3629. IF=3.864; Times Cited: 9
39. Zhuang, Yuan, Zhang Mengshi, Chen Bin, Duan Ruixue, Min Xuehong, Zhang Zhenyu, Zheng Fuxin, Liang Huageng, Zhao Zujin, Lou Xiaoding(*), Xia Fan, Quencher group induced high specificity detection of telomerase in clear and bloody urines by AIEgens, Analytical Chemistry, 2015, 87, 9487-9493. IF=6.042; Times Cited: 30
40. Lou, Xiaoding(#), Zhuang, Yuan(#), Zuo, Xiaolei(#), Jia, Yongmei, Hong, Yuning, Min, Xuehong, Zhang, Zhenyu, Xu, Xuemei, Liu, Nannan, Xia, Fan(*), Tang, Ben Zhong, Real-time, quantitative lighting-up detection of telomerase in urines of bladder cancer patients by AIEgens,Analytical Chemistry, 2015, 87, 6822-6827. IF=6.042; Times Cited: 66
41. Min, Xuehong(#), Zhuang, Yuan(#), Zhang, Zhenyu, Jia, Yongmei, Zheng, Fuxin, Cheng, Yong, Tang, Ben Zhong, Lou, Xiaoding(*), Xia, Fan, Lab in a tube: sensitive detection of microRNAs in urines samples from bladder cancer patients using a single-label DNA probe with AIEgens, ACS Applied Materials & Interfaces, 2015, 7, 16813-16818. IF=8.097; Times Cited: 24
