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化学系 | Department Of Chemistry
 

刘书琳

1、个人简介

刘书琳

现就职于中国地质大学(武汉),材料与化学学院,特任教授

电话:18162699633

微信:liusl1001

Emailshulin-liu@163.com

个人网址:

ResearchGate: https://www.researchgate.net/profile/Shulin_Liu6

GoogleScholar: https://scholar.google.com.hk/citations?user=F9tvz9YAAAAJ&hl=zh-CN

实验室网址:https://shulinliu2009.wixsite.com/liu-lab

欢迎有化学、材料、物理、生物及交叉学科背景的学生联系。招生对象包括博士后、研究生和本科生。我们将竭力营造平等、互助、友爱的科研环境,鼓励探索创新。共同学习,共同成长

2.教育与工作经历

2017. 09—至今,中国地质大学(武汉),材料与化学学院,特任教授

2013. 09—2017. 07,美国伊利诺伊大学芝加哥分校,化学学院,博士后(导师:WonhwaCho教授)

2007. 09—2013. 06,武汉大学,化学与分子科学学院,博士(导师:庞代文教授)

2003. 09—2007. 06,郑州大学,化学基地班专业,学士

3.个人研究成果

长期从事纳米生物医学成像及生物医学分析等方面的研究工作。在国际期刊上发表了SCI期刊论文22篇,其中第一作者的论文有10篇,总影响因子达到100多。代表性文章有Nature Chemical BiologyChemical Society ReviewsAngewandte Chemie International EditionACS Nano等。

4.主要研究领域

1)量子点的生物医学应用

2)纳米生物医学成像

3)单病毒示踪技术

4)新型显微镜成像技术

5.学术奖励情况

2017.04获得中国地质大学(武汉)“百人计划”支持。

2017. 03获得湖北省优秀博士论文称号。

2013. 03           获武汉大学第二届学术创新奖一等奖。

2012.12            荣获国家奖学金。

2012. 06           荣获武汉大学第一届学术创新奖一等奖。

2010. 11            2010年全国纳米生物医学会议上,墙报“利用量子点的单颗粒示踪技术研究WGA在活细胞内的转运机制”获得优秀墙报奖。

2006.06            荣获河南省“三好学生”称号。

6.代表性学术成果

(一)期刊论文

1.Liu, S. L.#; Sheng, R.#; Jung, J. H.; Wang, L.; Stec, E.; O'Connor, M. J.; Song, S.; Bikkavilli, R. K.; Winn, R. A.; Lee, D.; Baek, K.; Ueda, K.; Levitan, I.; Kim, K. P.; Cho, W., Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol. Nature chemical biology2017, 13 (3), 268-274.

2.         Liu, S. L.#; Wang, Z.G.#; Zhang, Z. L.; Pang, D. W., Tracking single viruses infecting their host cells using quantum dots.Chem. Soc. Rev. 2016, 45, 1211-122.

3.         Liu, S. L.; Sheng, R.; O'Connor, M. J.; Cui, Y.; Yoon, Y.; Kurilova, S.; Lee, D.; Cho, W., Simultaneous In Situ Quantification of Two Cellular Lipid Pools Using Orthogonal Fluorescent Sensors. Angewandte Chemie International Edition2014, 53 (52), 14387-14391.

4.         Liu, S. L.#; Li, J.#; Zhang, Z. L.; Wang, Z. G.; Tian, Z. Q.; Wang, G. P.; Pang, D. W., Fast and high-accuracy localization for three-dimensional single-particle tracking. Scientific reports 2013, 3, 2462.

5.         Liu, S. L.#; Tian, Z. Q.#; Zhang, Z. L.; Wu, Q. M.; Zhao, H. S.; Ren, B.; Pang, D. W., High-efficiency dual labeling of influenza virus for single-virus imaging. Biomaterials 2012, 33 (31), 7828-33.

6.         Liu, S. L.; Zhang, Z. L.; Tian, Z. Q.; Zhao, H. S.; Liu, H.; Sun, E. Z.; Xiao, G. F.; Zhang, W.; Wang, H. Z.; Pang, D. W., Effectively and efficiently dissecting the infection of influenza virus by quantum-dot-based single-particle tracking. ACS Nano 2012, 6 (1), 141-50.

7.         Liu, S. L.; Zhang, Z. L.; Sun, E. Z.; Peng, J.; Xie, M.; Tian, Z. Q.; Lin, Y.; Pang, D. W., Visualizing the endocytic and exocytic processes of wheat germ agglutinin by quantum dot-based single-particle tracking. Biomaterials 2011, 32 (30), 7616-24.

8.         Liu, S. L.#; Wu, Q. M.#; Zhang, L. J.; Wang, Z. G.; Sun, E. Z.; Zhang, Z. L.; Pang, D. W., Three-dimensional tracking Rab5- and Rab7- associated Infection Process of Influenza Virus. Small 2014, 10(22):4746-4753.

9.         Liu, S. L.#; Zhang, L. J.#; Wang, Z. G.; Zhang, Z. L.; Wu, Q. M.; Sun, E. Z.; Shi, Y. B.; Pang, D. W., Globally Visualizing the Microtubule-Dependent Transport Behaviors of Influenza Virus in Live Cells. Anal. Chem. 2014, 86 (8), 3902-3908.

10.       Wang, Z. G.#, Liu, S. L.#, Hu, Y. J., Tian, Z. Q., Hu B., Zhang, Z. L., Pang, D. W. Dissecting the factors affecting fluorescence stability of quantum dots in live cells. ACS Appl. Mater. Interfaces, 2016, 8 (13), 84018408.  

11.        Wang, Z. G.; Liu, S. L.; Tian, Z. Q.; Zhang, Z. L.; Tang, H. W.; Pang, D. W., Myosin-Driven Intercellular Transportation of Wheat Germ Agglutinin Mediated by Membrane Nanotubes between Human Lung Cancer Cells. ACS Nano 2012, 6 (11), 10033-41.

12.      Zhang, R. Q.; Liu, S. L.; Zhao, W.; Zhang, W.; Yu, X.; Li, Y.; Li, A. J.; Pang, D. W.; Zhang, Z. L., A Simple Rapid and Point-of-Care Microfluidic Immunomagnetic Fluorescence Assay for Pathogens. Anal. Chem. 2013, 85 (5), 264551.

13.       Chen, C.; Liu, S. L.; Cui, R.; Huang, B. H.; Tian, Z. Q.; Jiang, P.; Pang, D. W.; Zhang, Z. L., Diffusion behaviors of water-soluble CdSe/ZnS core/shell quantum dots investigated by single-particle tracking. J. Phys. Chem. C 2008, 112 (48), 18904-10.

14.       Wang, Z. G.; Liu, S. L.; Zhang, Z.L.; Tian, Z. Q.; Hong, W. T.; Pang, D. W., Exploring Sialic Acid Receptors-Related Infection Behavior of Avian Influenza Virus in Human Bronchial Epithelial Cells by Single-Particle Tracking. Small 2014. 10 (13), 2712-2720.

15.       Zhang, F.; Zheng, Z.; Liu, S. L.; Lu, W.; Zhang, Z.; Zhang, C.; Zhou, P.; Zhang, Y.; Long, G.; He, Z.; Pang, D. W.; Hu, Q.; Wang, H., Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking. Biomaterials 2013, 34 (30), 7506-18.

16.       Liu, H.; Liu, Y.; Liu, S.; Pang, D. W.; Xiao, G., Clathrin-mediated endocytosis in living host cells visualized through quantum dot labeling of infectious hematopoietic necrosis virus. Journal of Virology 2011, 85 (13), 6252-62.

17.      Shu, Y.; Lu, W.; Liu, S. L.; Xu, N.; Wang, L.; Zhang, L.; Zheng, Z. H.; Pang, D. W.; Wang, H. Z.; Zhang, Z.-L., Site-specific labeling of baculovirus in an integrated microfluidic device. Lab. Chip 2013, 13 (5), 860-865.

18.       Xie, M.; Luo, K.; Huang, B. H.; Liu, S. L.; Hu, J.; Cui, D.; Zhang, Z. L.; Xiao, G. F.; Pang, D. W., PEG-interspersed nitrilotriacetic acid-functionalized quantum dots for site-specific labeling of prion proteins expressed on cell surfaces. Biomaterials 2010, 31 (32), 8362-70.

19.       Hong, Z. Y.; Lv, C.; Liu, A. A.; Liu, S. L.; Sun, E. Z.; Zhang, Z. L.; Lei, A. W.; Pang, D. W., Clicking Hydrazine and Aldehyde: The Way to Labeling of Viruses with Quantum Dots. ACS nano 2015. DOI: 10.1021/acsnano.5b03256.

20.       Luo, Q. Y.; Lin Y.; Peng J.; Liu, S. L.; Zhang, Z. L.; Tian, Z. Q.; Pang, D. W.; Evaluation of nonspecific interactions between quantum dots and proteins. Phys. Chem. Chem. Phys. 2014, 16 (17), 7677-7680.

21 Cho, W.; Yoon, Y.; Liu, S. L.; Baek, K.; Sheng, R., Fluorescence-Based In Situ Quantitative Imaging for Cellular Lipids. Methods in enzymology2017, 583, 19-33.

22Sun, E. Z.; Liu, A. A.; Zhang, Z. L.; Liu, S. L.; Tian, Z. Q.; Pang, D. W., Real-Time Dissection of Distinct Dynamin-Dependent Endocytic Routes of Influenza A Virus by Quantum Dot-Based Single-Virus Tracking. ACS Nano 2017, 11 (5), 4395-4406.